Abstract Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support
many human cancers. Inhibition of COX-2 by celecoxib delays tumor growth and metastasis …

We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to
tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor …

Cyclooxygenasel (COX1) and COX2 mediate the rate‐limiting step in arachidonic acid me¬
tabolism. Expression of COX2 mRNA and protein is often enhanced in various human cell …

Both nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) 2-selective
inhibitors such as celecoxib are being reported as having potent anticancer activity in …

Abstract Purpose: Selective cyclooxygenase-2 (COX-2) inhibitors may suppress
carcinogenesis by both COX-2-dependent and COX-2-independent mechanisms. The …

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is the only non-steroidal anti-
inflammatory drug so far which has been approved by the FDA for adjuvant treatment of …

Abstract Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of
stimuli, suggesting that products of COX-2 may mediate critical steps. Here, we show that …

Background—Celecoxib has been shown to have antitumor effects that may be mediated
through the cyclooxygenase-independent inhibition of Akt signaling. Here, we examined the …

Angiogenesis plays a key role in the development of malignant tumors. To clarify the roles of
cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated …

PURPOSE. Eicosanoids that are present in inflamed tissues are thought to play a significant
role in angiogenesis. Cyclooxygenase, a key enzyme in eicosanoid synthesis, has recently …