Phospholipase C-γ1, a tyrosine kinase substrate, hydrolyses phosphatidylinositol 4, 5-
bisphosphate to produce inositol 1, 4, 5-trisphosphate and diacylglycerol, which act as …

Phospholipase C-γ1 (PLC-γ1) is rapidly activated in response to growth factor stimulation
and plays an important role in regulating cell proliferation and differentiation through the …

Phospholipase C-γ1 (PLC-γ1) activation has been reported to enhance cell survival during
the cellular response to oxidative stress. We studied the role of protein kinase C (PKC) …

Phosphatidylinositol-specific phospholipase C (PLC) activity reflects a summation of the
activities of three families, β, γ, and δ, each of which is regulated differently. In order to …

The activation of many tyrosine kinases leads to the phosphorylation and activation of
phospholipase C-γ1 (PLC-γ1). To examine the biological function of this protein …

In order to investigate the biological function of phosphatidylinositol‐specific phospholipase
C (PLC) we generated mutant mice by gene targeting. Homozygous inactivation of PLCβ3 is …

Phospholipase C (PLC) 1 hydrolyzes phosphatidylinositol 4, 5-bisphosphate to generate the
second messengers, inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 …

Phospholipase Cγ1 (PLC-γ1), a tyrosine kinase substrate, is a multi-domain molecule that
modulates the intracellular levels of the second messenger molecules: Ca2+ and …

The phospholipase C (PLC) family of cellular proteins participates in the intracellular
signaling mechanisms utilized by diverse growth factors (GFs). A wide variety of growth …

Abstract Phosphoinositide-specific phospholipase Cgamma (PLCgamma) is a key
regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain …