In a previous paper Cánovas et al.(Biotechnol Bioeng 2002; 77: 764–775) presented a
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …

In this work metabolic engineering strategies for maximizing l‐(–)‐carnitine production by
Escherichia coli based on the Biochemical System Theory (1–3) and the Indirect …

Signal transduction pathways are usually avoided when optimizing a biotransformation
process because they require complex mathematical formulations. The aim of this work was …

l-carnitine is a fine chemical with pharmaceutical, nutritional and animal food applications.
Thus, the product purification forms an essential part of the production process …

For the biotransformation of y-butyrobetaine into L-carnitine, a chemostat with cell-recycling
and a fed-batch process were developed and compared. Different cell recycling systems …

1. Abstract System Biology allows cellular complexity analysis and the optimization of cell
metabolic pathways by using cell component enumeration, structured relationship between …

The aim of this work is the rational design of microbial biocatalysts using Systems Biology
techniques. A stoichiometric model of the trimethylammonium compunds biotransformation …

The basis of a previous model for the crotonobetaine biotransformation into l (−)-carnitine by
Escherichia coli strains [Cánovas M, Maiquez JR, Obon JM, Iborra JL. Modeling of the …

A simple unstructured model, which includes carbon source as the limiting and essential
substrate and oxygen as an enhancing substrate for cell growth, has been implemented to …

L-(-)-carnitine ((R (-)-3hydroxy-4-trimethylaminobutyrate) is a compound involved in the
transport of long-chain fatty acids through the inner mitochondrial membrane. Several …