The Human Genome Project, DNA microarrays, proteome chips and metabolic profiles,
among others, are generating unprecedented amounts of valuable information about the …

Metabolism is highly complex and involves thousands of different connected reactions; it is
therefore necessary to use mathematical models for holistic studies. The use of …

To understand complex biological systems such as cells, tissues, or even the human body, it
is not sufficient to identify and characterize the individual molecules in the system. It also is …

Systems Biology has been defined in various ways since the term was first used less than
two decades ago, and the boundary between what does and does not constitute systems …

There is a renewed interest in obtaining a systemic understanding of metabolism, gene
expression and signal transduction processes, driven by the recent research focus on …

A true understanding of genetic and metabolic function and design is facilitated by
mathematical and computational methods for analyzing biochemical systems. This hands-on …

Mathematical modelling has great potential in biochemical network analysis because, in
contrast with the unaided human mind, mathematics has no problems keeping track of …

Biochemical systems biology augments more traditional disciplines, such as genomics,
biochemistry and molecular biology, by championing (i) mathematical and computational …

Novel high-throughput techniques are capable of producing dense time series of many
simultaneous in vivo measurements of the expression of genes, concentrations of …

Advances in genome sequencing, high throughput measurement of gene and protein
expression levels, data accessibility, and computational power have allowed genome‐scale …