Over the past 20 years, the incidence of cutaneous malignant melanoma (CMM) has
increased dramatically worldwide. A positive family history of the disease is among the most …

BACKGROUND Previous linkage studies have suggested prostate cancer susceptibility
genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate …

Genetic research on complex diseases is beginning to bear fruit, with the successful
identification of candidate susceptibility genes in diabetes, asthma, and other illnesses …

BACKGROUND: In 1989 the National Institute of Mental Health began a collaborative effort
to identify genes for bipolar disorder. The first 97 pedigrees showed evidence of linkage to …

We have previously reported strong evidence for linkage between IBD1 and Crohn's
disease (CD) in Australian Crohn's disease families. Three risk alleles for Crohn's …

Objective To identify genomic regions linked with determinants of age at symptom onset,
disease activity, and functional impairment in ankylosing spondylitis (AS). Methods A whole …

Background Coronary artery disease (CAD) is the leading cause of death and a leading
cause of disability in the developed world. Early onset (premature) coronary artery disease …

Linkage of IBD to the pericentromeric region of chromosome 16 has been widely confirmed
by analyses of multiple populations. The NOD2 gene is located in the peak region of linkage …

BACKGROUND Prostate cancer (CaP) is a common disorder with multiple genetic and
environmental factors contributing to the disease. CaP susceptibility loci can be identified …

Objective The ank/ank mouse develops a phenotype similar to ankylosing spondylitis (AS) in
humans. ANKH, the human homolog of the mutated gene in the ank/ank mouse, has been …