Heat shock protein (HSP) 60 nonspecifically activates cells of the innate immune system. In
the present study, we characterized the effects of human HSP60 maturation, cytokine …

Abstract Full-length Hsp70 protein (Hsp70) and the C-terminal domain of Hsp70 (Hsp70C)
both stimulate the cytolytic activity of naive natural killer (NK) cells against Hsp70-positive …

ABSTRACT CD40 has emerged as a key signaling pathway for the function of B cells,
monocytes, and dendritic cells (DC) in the immune system, and plays a major role in …

The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe
birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years …

Thrombospondin (TSP) signals focal adhesion disassembly (the intermediate adhesive
state) through interactions with cell surface calreticulin (CRT). TSP or a peptide (hep I) of the …

Soluble 60 kDa heat shock protein (HSP60) activates macrophages via TLR4. We now
report that soluble HSP60 activates T cells via the innate receptor TLR2. HSP60 activated T …

Heat shock proteins have been implicated as endogenous activators for dendritic cells
(DCs). Without tissue distress or death, these intracellular molecules are inaccessible to …

Amongst the families of intracellular molecules that chaperone and assist with the trafficking
of other proteins, notably during conditions of cellular stress, heat shock protein (hsp) 70 is …

Viral hepatitis B is an enigmatic disease in which the host's own immune response to
persistent viral infection may bring about host destruction through antiviral inflammatory …

In this Part III of the review, experimental and clinical data from the literature are presented in
support of the concept that both the early and late fate of an allograft are predominantly …