Heat shock proteins (hsp) 96 play an essential role in protein metabolism and exert
stimulatory activities on innate and adaptive immunity. Vaccination with tumor-derived hsp96 …

Fever is a phylogenetically conserved biological phenomenon and a common consequence
of infection. Here, we examine in vitro and in vivo the effect of febrile temperature on …

We have previously reported that apoptotic tumor cells can be either immunogenic or
nonimmunogenic in vivo, depending on whether or not these cells are heat stressed before …

Apoptosis, a physiological process of self-annihilation, is essential during development and
for the maintenance of tissue homeostasis. Considerable efforts have been made in recent …

This report defines a novel approach to heat shock protein vaccine formulation that takes
advantage of the chaperoning property of heat shock protein hsp110 to efficiently bind a …

It is well established that activating-type Fc receptors for IgG (FcγR), such as FcγRI and
FcγRIII, are essential for inducing inflammatory responses, whereas a unique inhibitory …

Gp96 is an endoplasmic reticular heat shock protein (HSP). We have shown previously that
surface expression of gp96 (96tm) on tumor cells led to the activation of dendritic cells and …

Tumor-secreted gp96-Ig is highly immunogenic and triggers CD8 T cell-mediated tumor
rejection. In vivo secreted gp96-Ig and gp96-myc cause NK activation and clonal expansion …

The cardinal role of dendritic cells (DC) in priming adaptive immunity and in orchestrating
immune responses against all classes of pathogens and also against tumors is well …

We have utilized a free-solution isoelectric focusing technique (FS-IEF) to obtain chaperone-
rich cell lysate (CRCL) fractions from clarified tumor homogenates and have previously …