Vaccination with heat shock protein–peptide complexes: from basic science to clinical applications
A Hoos, DL Levey - Expert Review of Vaccines, 2003 - Taylor & Francis
There are currently over 150 medical centers worldwide enrolling patients in randomized,
controlled Phase III clinical trials testing autologous cancer-derived heat-shock protein …
controlled Phase III clinical trials testing autologous cancer-derived heat-shock protein …
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma
B Farkas, M Hantschel, M Magyarlaki… - Melanoma …, 2003 - journals.lww.com
Cell membrane localization of the 72 kDa heat shock protein 70 (Hsp70) has been found on
different tumour cell lines, on biopsy material from solid tumours and metastases and on …
different tumour cell lines, on biopsy material from solid tumours and metastases and on …
The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions
MP Radsak, N Hilf, H Singh-Jasuja… - Blood, The Journal …, 2003 - ashpublications.org
The endoplasmic reticulum (ER)–resident heat shock protein Gp96 is involved in protein
folding and is released into the extracellular space after necrotic cell death. In this context …
folding and is released into the extracellular space after necrotic cell death. In this context …
Immunization with tumorderived ER chaperone grp170 elicits tumorspecific CD8+ Tcell responses and reduces pulmonary metastatic disease
XY Wang, L Kazim, EA Repasky… - International journal of …, 2003 - Wiley Online Library
Abstract Glucoseregulated protein (grp) 170 is a molecular chaperone localized in
endoplasmic reticulum (ER), which has been demonstrated to interact with the peptides …
endoplasmic reticulum (ER), which has been demonstrated to interact with the peptides …
Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity
W van Eden, A Koets, P van Kooten, B Prakken… - Vaccine, 2003 - Elsevier
Heat shock proteins (hsps) are known to be immunodominant antigens of bacteria. Hsps are
evolutionarily strongly conserved proteins present in all eukaryotic and prokaryotic cellular …
evolutionarily strongly conserved proteins present in all eukaryotic and prokaryotic cellular …
Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers
MW Graner, Y Zeng, H Feng, E Katsanis - Cancer Immunology …, 2003 - Springer
With the clinical use of purified, tumor-derived chaperone proteins as anti-cancer vaccines
already in clinical trial stages, we have focused our attention on the utility of chaperone-rich …
already in clinical trial stages, we have focused our attention on the utility of chaperone-rich …
Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in …
JO Jones, AM Arvin - Journal of virology, 2003 - Am Soc Microbiol
During primary infection, varicella-zoster virus (VZV) is spread via lymphocytes to skin,
where it induces a rash and establishes latency in sensory ganglia. A live, attenuated …
where it induces a rash and establishes latency in sensory ganglia. A live, attenuated …
Hyperthermia improves cellular immune response to human hepatocellular carcinoma subsequent to co-culture with tumor lysate pulsed dendritic cells
G Schueller, A Stift, J Friedl… - International …, 2003 - spandidos-publications.com
Dendritic cells play a major role in cellular immunity. The crucial steps of antigen
presentation and processing by DCs may be limiting factors for adoptive cellular …
presentation and processing by DCs may be limiting factors for adoptive cellular …
Adjuvants for vaccines, a quest
F Audibert - International immunopharmacology, 2003 - Elsevier
Efficient vaccines comprise a specific moiety: the structures presenting the protective
antigenic determinants, and a nonspecific moiety: the adjuvant components. Dramatic …
antigenic determinants, and a nonspecific moiety: the adjuvant components. Dramatic …
ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection
JC Baker-LePain, RC Reed, CV Nicchitta - Current opinion in immunology, 2003 - Elsevier
Heat shock/chaperone protein (HSCP)–peptide complexes can access the cross-priming
pathways of antigen presenting cells (APCs), and the gp96-associated peptides can be re …
pathways of antigen presenting cells (APCs), and the gp96-associated peptides can be re …