gp96 (GRP94) elicits antigen-presenting cell (APC) activation and can direct peptides into
the cross-presentation pathways of APC. These responses arise through interactions of …

Calreticulin and gp96 (GRP94) traffic associated peptides into the major histocompatibility
complex class-I cross-presentation pathway of antigen-presenting cells (APCs). Efficient …

Class A scavenger receptors (SR-A) are transmembrane glycoproteins that mediate both
ligand internalization and cell adhesion. Previous studies have identified specific amino …

Abstract GRP94 (gp96) elicits CD8+ T cell responses against its bound peptides, a process
requiring access of its associated peptides into the MHC class I cross-presentation pathway …

Scavenger receptors constitute a family of cell surface receptors that internalize endotoxins,
oxidized lowdensity lipoproteins (oxLDL) and other proteins with clustered negative …

We report the cloning of a novel human type I cell surface Ag mainly expressed by
macrophages. The primary structure was established by molecular cloning, which yielded a …

Apoptotic cells (AC) must be cleared by macrophages (Mø) to resolve inflammation
effectively. Mertk and scavenger receptor A (SR-A) are two of many receptors involved in AC …

Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage
functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to …

Extracellular heat shock protein 70 (Hsp70) exerts profound effects both in mediating tumor
rejection by Hsp70-based vaccines and in autoimmunity. Further progress in this area …

Antigen presenting cells (APCs) can take up exogenous antigenic peptides chaperoned by
heat shock protein gp96 and re-present them through the endogenous pathway on their …