Cryptococcosis is a major threat to immunocompromised individuals. Isolates of
Cryptococcus neoformans var. grubii and var. neoformans are responsible for most of the …

Gene disruption in Cryptococcus neoformans can be problematic due to high frequencies of
ectopic integration and telomerization. To improve the frequency of homologous integration …

Gene disruption by biolistic transformation in serotype D strains of Cryptococcus
neoformans. Fungal Genetics and Biology29, 38–48. Cryptococcus neoformans is an …

Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle
for which genetic and molecular techniques are well developed. The entire genome …

The accumulation of genomic structural variation between closely related populations over
time can lead to reproductive isolation and speciation. The fungal pathogen Cryptococcus is …

Received wisdom in the field of fungal biology holds that the process of editing a genome by
transformation and homologous recombination is inherently mutagenic. However, that belief …

Cryptococcus neoformans and Cryptococcus gattii are basidiomycetous fungi that infect
immunocompromised and immunocompetent people. We developed an insertional …

Cryptococcus neoformans is a pathogenic fungus that is relatively amenable to molecular
genetic analysis, including gene deletion. However, rates of homologous recombination can …

Just as Koch's postulates formed the foundation of early infectious disease study, Stanley
Falkow's molecular Koch's postulates define best practice in determining whether a specific …

Cryptococcus neoformans is an opportunistic human fungal pathogen and serves as a
model organism for studies of eukaryotic microbiology and microbial pathogenesis. C …