The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
F Fuks, PJ Hurd, R Deplus… - Nucleic acids research, 2003 - academic.oup.com
The DNA methyltransferases, Dnmts, are the enzymes responsible for methylating DNA in
mammals, which leads to gene silencing. Repression by DNA methylation is mediated partly …
mammals, which leads to gene silencing. Repression by DNA methylation is mediated partly …
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
H Kimura, K Shiota - Journal of Biological Chemistry, 2003 - ASBMB
During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
DNA methyltransferases get connected to chromatin
WA Burgers, F Fuks, T Kouzarides - TRENDS in Genetics, 2002 - cell.com
The DNA methyltransferases (Dnmts) are responsible for the generation of genomic
methylation patterns, which lead to transcriptional silencing. Recent studies have identified …
methylation patterns, which lead to transcriptional silencing. Recent studies have identified …
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern
J Espada, E Ballestar, MF Fraga, A Villar-Garea… - Journal of Biological …, 2004 - ASBMB
DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is
thought to be the enzyme primarily responsible for maintenance of the global methylation …
thought to be the enzyme primarily responsible for maintenance of the global methylation …
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
Molecular coupling of DNA methylation and histone methylation
H Hashimoto, PM Vertino, X Cheng - Epigenomics, 2010 - Taylor & Francis
The combinatorial pattern of DNA and histone modifications constitutes an epigenetic 'code
'that shapes gene-expression patterns by enabling or restricting the transcriptional potential …
'that shapes gene-expression patterns by enabling or restricting the transcriptional potential …
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
Functional cooperation between HP1 and DNMT1 mediates gene silencing
A Smallwood, PO Estève, S Pradhan… - Genes & …, 2007 - genesdev.cshlp.org
Mammalian euchromatic gene silencing results from the combined repressive effects of
histone and DNA methyltransferases. Little is known of the mechanism by which these …
histone and DNA methyltransferases. Little is known of the mechanism by which these …
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin
DNA methylation and histone modification are two major epigenetic pathways that interplay
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …