There is compelling evidence that the etiology of Alzheimer's disease (AD) involves
characteristic amyloid-β (Aβ) deposition, oxidative stress, and anomalous metal–Aβ protein …

Zinc is an essential trace element in human biology, but is neurotoxic at high concentrations.
Several studies show that zinc promotes aggregation of β-amyloid protein, the main …

Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …

Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and
in disease. Zinc is released into the synaptic cleft of glutamatergic neurons alongside …

Alzheimer's disease (AD) is associated with the abnormal aggregation of amyloid-beta (Aβ)
protein. Aβ and its precursor protein (APP) interact with metal ions such as zinc, copper and …

Mounting evidence is demonstrating roles for the amyloid precursor protein (APP) and its
proteolytic product Aβ in metal homeostasis. Furthermore, aberrant metal homeostasis is …

Despite serving a crucial purpose in neurobiological function, transition metals play a
sinister part in the aging brain, where the abnormal accumulation and distribution of reactive …

Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc
and exogenous ones such as aluminum, can be involved as factors or cofactors in the …

Zinc is one of the most abundant transition metals in the brain. A substantial fraction (10–
15%) of brain zinc is located inside presynaptic vesicles of certain glutamatergic terminals in …

Alzheimer's disease is the most common form of dementia in the elderly, and it is
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …