Osteoarthritis (OA) is the most common human joint disease, characterized by loss and/or
remodeling of joint synovium, cartilage, and bone. Here, we describe a genomewide linkage …

Background: Seven polymorphisms in the matrilin-3 (MATN3) gene were previously tested
for genetic association with hand osteoarthritis in an Icelandic cohort. One of the variants …

Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of
disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the …

Objective Studies investigating hand osteoarthritis (OA) as a single entity have not shown
strong linkage of the disease with any chromosomal sites. We undertook this study to test …

Several mutations in the extracellular matrix protein matrilin-3 cause a heterogeneous
disease spectrum affecting skeletal tissues. We introduced three disease causing point …

Objective To search for markers linked to quantity of radiographic hand osteoarthritis (OA) in
the Framingham Heart Study. Methods The sample included 684 original cohort members …

Background In search for genes predisposing to osteoarthritis (OA), several genome wide
scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region …

Background and objective: Until recently, there has been little agreement between
conflicting results of osteoarthritis (OA) linkage. The purpose of this study was to conduct a …

Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

OBJECTIVE: To evaluate biological markers as potential quantitative traits of clinical
osteoarthritis (OA) in a large multigenerational family in the Carolinas of the USA known as …