The determination of the amino acid sequence of quinolone resistance-determining regions
(QRDRs) in the A and B subunits of DNA gyrase is the molecular test for the detection of …

The sequences of a conserved region in the A subunit of DNA gyrase corresponding to the
quinolone resistance-determining region were determined for nine mycobacterial species …

Fluoroquinolone-resistant mutants of Mycobacterium smegmatis have been obtained in vitro
by using ofloxacin as a selecting agent. Two types of mutants were identified according to …

The in vitro activities of seven quinolones and the sequences of the quinolone resistance-
determining regions (QRDR) in the A and B subunits of DNA gyrase were determined for 14 …

We report the cloning and characterization of the gyrA gene of the Mycoplasma hominis
DNA gyrase, which was previously shown to be associated with quinolone resistance in this …

The mutations in the quinolone resistance-determining region of the gyrA gene from clinical
isolates of Pseudomonas aeruginosa were determined by DNA sequencing. The strains …

Chromosomal DNA of different species of mycobacteria, Mycobacterium tuberculosis,
Mycobacterium leprae, Mycobacterium avium and Mycobacterium smegmatis, has been …

Plasmid pJSW101 derived from pUC19 and carrying the wild-type gyrA gene was found to
be unstable in HM72, a quinolone-resistant (QR) clinical isolate of Escherichia coli, and …

The DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and
Mycobacterium fortuitum bv. peregrinum, which are species naturally resistant, moderately …

Two plasmids containing the cloned Escherichia coli wild-type gyrA gene were used to
transform ciprofloxacin-resistant Gram-negative clinical isolates to screen for DNA gyrase A …