[HTML][HTML] Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26: implication for key amino acid residues for channel formation and function
A Oshima, T Doi, K Mitsuoka, S Maeda… - Journal of Biological …, 2003 - ASBMB
Connexins form a family of membrane proteins that assemble into communication channels
and directly connect the cytoplasms of adjoining cells. Malfunctioning of connexin channels …
and directly connect the cytoplasms of adjoining cells. Malfunctioning of connexin channels …
[HTML][HTML] The N terminus of connexin37 contains an α-helix that is required for channel function
JW Kyle, VM Berthoud, J Kurutz, PJ Minogue… - Journal of Biological …, 2009 - ASBMB
The cytoplasmic N-terminal domain of connexins has been implicated in multiple aspects of
gap junction function, including connexin trafficking/assembly and channel gating. A …
gap junction function, including connexin trafficking/assembly and channel gating. A …
An intact connexin N-terminus is required for function but not gap junction formation
JW Kyle, PJ Minogue, BC Thomas… - Journal of cell …, 2008 - journals.biologists.com
The cytoplasmic N-termini of connexins have been implicated in protein trafficking,
oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 …
oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 …
Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43
V Lagrée, K Brunschwig, P Lopez… - Journal of cell …, 2003 - journals.biologists.com
To identify signals that convey connexin oligomerization compatibility, we have aligned
amino-acid sequences of α and β group connexins (Cx) and compared the physico …
amino-acid sequences of α and β group connexins (Cx) and compared the physico …
[HTML][HTML] The pattern of disulfide linkages in the extracellular loop regions of connexin 32 suggests a model for the docking interface of gap junctions
CI Foote, L Zhou, X Zhu, BJ Nicholson - The Journal of cell biology, 1998 - ncbi.nlm.nih.gov
Connexins, like true cell adhesion molecules, have extracellular domains that provide strong
and specific homophilic, and in some cases, heterophilic interactions between cells. Though …
and specific homophilic, and in some cases, heterophilic interactions between cells. Though …
[HTML][HTML] Mutation of a conserved threonine in the third transmembrane helix of α-and β-connexins creates a dominant-negative closed gap junction channel
DL Beahm, A Oshima, GM Gaietta, GM Hand… - Journal of Biological …, 2006 - ASBMB
Single site mutations in connexins have provided insights about the influence specific amino
acids have on gap junction synthesis, assembly, trafficking, and functionality. We have …
acids have on gap junction synthesis, assembly, trafficking, and functionality. We have …
Mutations of connexin 26 at position 75 and dominant deafness: essential role of arginine for the generation of functional gap-junctional channels
Y Deng, Y Chen, L Reuss, GA Altenberg - Hearing research, 2006 - Elsevier
Gap-junctional channels are large intercellular aqueous pores formed by head-to-head
association of two gap-junctional hemichannels (connexin hexamers), one from each of the …
association of two gap-junctional hemichannels (connexin hexamers), one from each of the …
Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels
PEM Martin, G Blundell, S Ahmad… - Journal of cell …, 2001 - journals.biologists.com
The assembly of gap junctions was investigated in mammalian cells expressing connexin
(Cx) 26, 32 and 43 fused to green, yellow or cyan fluorescent proteins (GFP, YFP, CFP) …
(Cx) 26, 32 and 43 fused to green, yellow or cyan fluorescent proteins (GFP, YFP, CFP) …
[HTML][HTML] Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability
C Ambrosi, D Boassa, J Pranskevich, A Smock… - Biophysical journal, 2010 - cell.com
Connexin26 is a ubiquitous gap junction protein that serves critical homeostatic functions.
Four single-site mutations found in the transmembrane helices (M1–M4) cause different …
Four single-site mutations found in the transmembrane helices (M1–M4) cause different …
[HTML][HTML] Functional expression in Xenopus oocytes of gap-junctional hemichannels formed by a cysteine-less connexin 43
Gap-junctional channels are formed by two connexons or gap-junctional hemichannels in
series, with each connexon conformed by six connexin molecules. As with other membrane …
series, with each connexon conformed by six connexin molecules. As with other membrane …