Because angiogenesis is essential for tumor growth and metastasis, inhibition of
angiogenesis has emerged as a new therapy to treat cancers. Hypoxia-induced expression …

Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a
possible relationship between circadian rhythms and tumorigenesis. However, the precise …

Disturbance in the expression of circadian rhythm genes is a common feature in certain
types of cancer, however the mechanisms mediating this disturbance remain to be …

Background Circadian clocks control cell cycle factors, and circadian disruption promotes
cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle …

Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …

Circadian rhythms are the daily oscillations of multiple biological processes regulated by an
endogenous clock. The Period2 gene is essential in controlling the circadian rhythm and …

Circadian rhythms control multiple physiological and pathological processes, including
embryonic development in mammals and development of various human diseases. We …

Circadian clock systems regulate many biologic functions, including cell division and
hormone secretion in mammals. In this study, we explored the effects of circadian control on …

Altered circadian rhythms predicted for poor survival in patients with metastatic colorectal or
breast cancer. An increased incidence of cancers has been reported in flying attendants and …

Proper circadian regulation is essential for the well being of the organism, and disruption of
circadian rhythms is associated with pathological conditions including cancer. In mammals …