The physiological properties of most ion channels are defined experimentally by functional
expression of their pore-forming α subunits in Xenopus laevis oocytes. Here, we cloned a …

Once again, a MinK-related peptide (MiRP) has been implicated in allowing a pore-forming,
voltage-gated potassium channel α subunit to achieve its potential. In this issue of …

Abstract Kv2. 1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier
currents in mammalian heart and brain. The biophysical properties of Kv2. 1 and other ion …

Voltage-gated potassium (Kv) channels extend their functional repertoire by coassembling
with MinK-related peptides (MiRPs). MinK slows the activation of channels formed with …

KCNE2, originally designated MinK-related peptide 1 (MiRP1), belongs to a five-strong
family of potassium channel ancillary (β) subunits that, despite the diminutive size of the …

Xenopus oocytes injected with GIRK1 mRNA express inwardly rectifying K+ channels
resembling I KACh. Yet I KACh, the atrial G protein–regulated ion channel, is a …

The low-dielectric plasma membrane provides an energy barrier hindering transmembrane
movement of charged particles. The positively charged, voltage-sensing fourth …

Non‐technical summary Due to the conservation of developmental pathways and genetic
material over the course of evolution, non‐mammalian 'model organisms' such as the …

Voltage-gated potassium (Kv) channels mediate rapid, selective diffusion of K+ ions through
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …

1. INTRODUCTION 3581.1 Summary 3581.2 Overview 3591.3 Four classes of pore-forming
K+ channel subunits–necessary and (sometimes) sufficient 3611.4 Soluble and peripheral …