DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies widely
among different organisms. Even within animal genomes, methylation patterns vary …

We have been studying the evolution and function of DNA methylation in vertebrate animals
using three related approaches. The first is to further characterise proteins that bind to …

Abstract Background Methylation at CpG dinucleotides in genomic DNA is a fundamental
epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl …

CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

CpG methylation in vertebrates is important for gene silencing, alterations in chromatin
structure and genomic stability, and differences in the DNA-methylation status are correlated …

ABSTRACT DNA methylation is an epigenetically inherited chemical modification that is
associated with transcriptional silencing and is essential for mammalian development. The …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …

DNA methylation is an epigenetic mark that is essential for the development of mammals; it
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …