The endothelium in health and disease-a target for therapeutic intervention

CR Triggle, M Hollenberg, TJ Anderson… - Journal of Smooth …, 2003 - jstage.jst.go.jp
In this review we discuss the contribution of NO, prostacyclin and endotheliumderived
relaxing factor—endothelium-derived hyperpolarizing factor, or EDHF, to vascular function …

The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in …

CR Triggle, H Ding, TJ Anderson… - Molecular and cellular …, 2004 - Springer
Endothelial dysfunction is considered as a major risk factor of cardiovascular complications
of type I and types II diabetes. Impaired endothelium-dependent vasodilatation can be …

Novel endothelium-derived relaxing factors: identification of factors and cellular targets

H Ding, CR Triggle - Journal of pharmacological and toxicological methods, 2000 - Elsevier
Nitric oxide (NO), together with prostacyclin (PGI2), mediates shear stress and endothelium-
dependent vasodilator-mediated vasorelaxation. In the presence of inhibition of NO …

[HTML][HTML] EDHF–are there gaps in the pathway?

G Edwards, AH Weston - The Journal of Physiology, 2001 - ncbi.nlm.nih.gov
Vascular endothelial cells release a variety of vasorelaxant factors in response to stretch or
to agonists. Attention has mainly focused on two such factors, prostacyclin and nitric oxide …

Endothelium-derived hyperpolarizing factor: where are we now?

M Félétou, PM Vanhoutte - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

[HTML][HTML] Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

T Matoba, H Shimokawa, M Nakashima… - The Journal of …, 2000 - Am Soc Clin Investig
The endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several endothelium-derived relaxing factors, such as …

Contribution of endothelium‐derived hyperpolarizing factors to the regulation of vascular tone in humans

J Bellien, C Thuillez… - Fundamental & clinical …, 2008 - Wiley Online Library
Endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the
release of vasoactive factors. Besides nitric oxide (NO) and prostacyclin, increasing …

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans

T Matoba, H Shimokawa - Journal of pharmacological sciences, 2003 - jstage.jst.go.jp
Vascular endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide …

Hydrogen peroxide as an endothelium-derived hyperpolarizing factor

H Shimokawa, T Matoba - Pharmacological research, 2004 - Elsevier
Vascular endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide …

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and …

RP Brandes, FH Schmitz-Winnenthal… - Proceedings of the …, 2000 - National Acad Sciences
In addition to nitric oxide (NO) and prostacyclin (PGI2), the endothelium generates the
endothelium-derived hyperpolarizing factor (EDHF). We set out to determine whether an …