Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …

Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …

It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the developed
world. The increasing life expectancy in the last years has led to an increase in the …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Several recent advances have provided new insights and possibilities in defining
therapeutic targets for Alzheimer's disease. Of particular importance is the identification of …

In the last decade, advances in understanding the neurobiology of Alzheimer's disease (AD)
have translated into an increase in clinical trials assessing various potential AD treatments …

The bulk of AD research during the last 25 years has been Aβ-centric based on a strong faith
in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date …

Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …