▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

Advances in the understanding of the cells of the hematopoietic system have provided a rich
basis for improving clinical hematopoietic cell transplants; finding and using proteins and …

Background The highly orchestrated process of blood cell development and homeostasis is
termed “hematopoiesis.” Understanding the biology of hematopoietic stem cells as well as …

Rarely has so much interest from the lay public, government, biotechnology industry, and
special interest groups been focused on the biology and clinical applications of a single type …

Considerable efforts have been made in recent years in understanding the mechanisms that
govern hematopoietic stem cell (HSC) origin, development, differentiation, self-renewal …

To elucidate the molecular mechanisms underlying normal and malignant hematopoietic
development, it is critical to identify developmental intermediates for each lineage …

Understanding the processes that regulate the developmental program of normal stem cells
and those that initiate proliferative diseases such as leukemia remains one of the major …

A vast literature exists on the biology of blood formation and regeneration under
experimental and clinical conditions. The field of hematopoiesis was recently advanced by …

The genetic engineering of hematopoietic stem cells is the basis for potentially treating a
large array of hereditary and acquired diseases, and stands as the paradigm for stem cell …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …