Causative and susceptibility genes for Alzheimer's disease: a review
A Rocchi, S Pellegrini, G Siciliano, L Murri - Brain research bulletin, 2003 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …
Three genes have been identified as responsible for the rare early-onset familial form of the …
Apolipoprotein E alleles as risk factors in Alzheimer's disease
AD Roses, MD - Annual review of medicine, 1996 - annualreviews.org
▪ Abstract Alzheimer's disease (AD) is unique in medicine in that millions of people suffer
from what appears to be the same form of disease, and unlike most other late-onset …
from what appears to be the same form of disease, and unlike most other late-onset …
Molecular genetics of late‐onset Alzheimer's disease
MI Kamboh - Annals of human genetics, 2004 - Wiley Online Library
Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the
possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE* 4 …
possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE* 4 …
[引用][C] Apolipoprotein E affects the rate of Alzheimer disease expression: β-amyloid burden is a secondary consequence dependent on APOE genotype and duration …
AD Roses - Journal of Neuropathology & Experimental …, 1994 - academic.oup.com
Background The present forum for simultaneous publication of apparently conficting
hypotheses about the pathogenesis of Alzheimer disease (AD) provides the opportunity to …
hypotheses about the pathogenesis of Alzheimer disease (AD) provides the opportunity to …
Genetic aspects of Alzheimer disease
J Williamson, J Goldman, KS Marder - The neurologist, 2009 - journals.lww.com
Background: Alzheimer disease (AD) is a genetically complex disorder. Mutations in 3
genes, presenilin 1, amyloid precursor protein, and presenilin 2, lead to early-onset familial …
genes, presenilin 1, amyloid precursor protein, and presenilin 2, lead to early-onset familial …
Alzheimer's disease: a re-examination of the amyloid hypothesis
RL Neve, NK Robakis - Trends in neurosciences, 1998 - cell.com
Alzheimer's disease (AD) is a neurodegenerative disorder of the brain characterized by the
presence of neuritic amyloid plaques and neurofibrillary tangles. Although it most frequently …
presence of neuritic amyloid plaques and neurofibrillary tangles. Although it most frequently …
Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE …
Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the elderly.
Predominantly this disease is sporadic in nature with only a small percentage of patients …
Predominantly this disease is sporadic in nature with only a small percentage of patients …
Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease
DK Lahiri, K Sambamurti, DA Bennett - Neurobiology of aging, 2004 - Elsevier
Herein we review the role of apolipoprotein E (ApoE) in Alzheimer's disease (AD) and how
ApoE interacts with various risk factors. ApoE is localized with the major pathological …
ApoE interacts with various risk factors. ApoE is localized with the major pathological …
Alzheimer's disease: one disorder, too many genes?
The research of Alzheimer's disease (AD) genetics has been extremely prolific over the past
decade, and currently more than 10 genes are reported to show either positive or negative …
decade, and currently more than 10 genes are reported to show either positive or negative …
The Alzheimer diseases
AD Roses - Current opinion in neurobiology, 1996 - Elsevier
Our understanding of the etiologies of the Alzheimer diseases is advancing rapidly, led by
the discovery of relevant genetic mutations for autosomal-dominant forms of the disease and …
the discovery of relevant genetic mutations for autosomal-dominant forms of the disease and …