Evolution and classification of P-loop kinases and related proteins
Sequences and structures of all P-loop-fold proteins were compared with the aim of
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …
Novel families of putative protein kinases in bacteria and archaea: evolution of the “eukaryotic” protein kinase superfamily
The central role of serine/threonine and tyrosine protein kinases in signal transduction and
cellular regulation in eukaryotes is well established and widely documented. Considerably …
cellular regulation in eukaryotes is well established and widely documented. Considerably …
Simple yet functional phosphate-loop proteins
ML Romero Romero, F Yang, YR Lin… - Proceedings of the …, 2018 - National Acad Sciences
Abundant and essential motifs, such as phosphate-binding loops (P-loops), are presumed to
be the seeds of modern enzymes. The Walker-A P-loop is absolutely essential in modern …
be the seeds of modern enzymes. The Walker-A P-loop is absolutely essential in modern …
[HTML][HTML] Serine/threonine protein kinases from bacteria, archaea and eukarya share a common evolutionary origin deeply rooted in the tree of life
The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined
and described by Hanks et al. in 1988 (Science, 241, 42–52). It was initially believed that …
and described by Hanks et al. in 1988 (Science, 241, 42–52). It was initially believed that …
[HTML][HTML] On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment
This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last
universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous …
universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous …
[HTML][HTML] Structural and functional diversity of the microbial kinome
The eukaryotic protein kinase (ePK) domain mediates the majority of signaling and
coordination of complex events in eukaryotes. By contrast, most bacterial signaling is …
coordination of complex events in eukaryotes. By contrast, most bacterial signaling is …
Tracing the origin and evolution of pseudokinases across the tree of life
Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome
J Perez, A Castaneda-Garcia… - Proceedings of the …, 2008 - National Acad Sciences
Ser/Thr/Tyr kinases, which together comprise a major class of regulatory proteins in
eukaryotes, were not believed to play an important role in prokaryotes until recently …
eukaryotes, were not believed to play an important role in prokaryotes until recently …
Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry
PJ Kennelly - Biochemical Journal, 2003 - portlandpress.com
Protein phosphorylation/dephosphorylation has long been considered a recent addition to
Nature's regulatory arsenal. Early studies indicated that this molecular regulatory …
Nature's regulatory arsenal. Early studies indicated that this molecular regulatory …
Evolution of two-component signal transduction
KK Koretke, AN Lupas, PV Warren… - Molecular biology …, 2000 - academic.oup.com
Two-component signal transduction (TCST) systems are the principal means for
coordinating responses to environmental changes in bacteria as well as some plants, fungi …
coordinating responses to environmental changes in bacteria as well as some plants, fungi …