Sequences and structures of all P-loop-fold proteins were compared with the aim of
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …

The central role of serine/threonine and tyrosine protein kinases in signal transduction and
cellular regulation in eukaryotes is well established and widely documented. Considerably …

Abundant and essential motifs, such as phosphate-binding loops (P-loops), are presumed to
be the seeds of modern enzymes. The Walker-A P-loop is absolutely essential in modern …

The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined
and described by Hanks et al. in 1988 (Science, 241, 42–52). It was initially believed that …

This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last
universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous …

The eukaryotic protein kinase (ePK) domain mediates the majority of signaling and
coordination of complex events in eukaryotes. By contrast, most bacterial signaling is …

Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …

Ser/Thr/Tyr kinases, which together comprise a major class of regulatory proteins in
eukaryotes, were not believed to play an important role in prokaryotes until recently …

Protein phosphorylation/dephosphorylation has long been considered a recent addition to
Nature's regulatory arsenal. Early studies indicated that this molecular regulatory …

Two-component signal transduction (TCST) systems are the principal means for
coordinating responses to environmental changes in bacteria as well as some plants, fungi …