The chemotactic factors directing interneuron migration during cerebrocortical development
are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in …

Interneurons are born in subcortical germinative zones and tangentially migrate in multiple
streams above and below the developing cortex, and then, at the appropriate developmental …

The CXCL12/CXCR4 signaling pathway is involved in the development of numerous
neuronal and non-neuronal structures. Recent work established that the atypical second …

CXCL12/CXCR4 signaling is critical for cortical interneuron migration and their final laminar
distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor …

Summary The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration
in multiple biological contexts, including brain development, leukocyte trafficking, and …

Functioning of the cerebral cortex requires the coordinated assembly of circuits involving
glutamatergic projection neurons and GABAergic interneurons. Although much is known …

Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal
granular layer (IGL) is a crucial process in the development of the mammalian cerebellar …

Chemotactic cytokines (chemokines) are small secreted proteins that control leukocyte
trafficking in immune organs. Chemokines which are induced in the brain during conditions …

The molecular mechanisms that sort migrating neural crest cells (NCCs) along a shared
pathway into two functionally discrete structures, the dorsal root ganglia and sympathetic …

We investigated the role of the CXCR4 chemokine receptor in development of the mouse
hippocampus. CXCR4 mRNA is expressed at sites of neuronal and progenitor cell migration …