purpose. Mutations in the frizzled-4 gene (FZD4) have recently been associated with
autosomal dominant familial exudative vitreoretinopathy (FEVR) in families linking to the …

The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities
activating either the canonical Wnt/β-catenin pathway or Fz/planar cell polarity (PCP) …

Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a
diverse array of developmental processes, many of which depend upon the precise …

Objective: FrzA, a member of the group of secreted frizzled related proteins (sFRP) that is
expressed in the cardiovascular system, has been shown to antagonize the Wnt/frizzled …

The Hedgehog signalling pathway is deployed repeatedly during normal animal
development and its inappropriate activity is associated with various tumours in human. The …

A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP)
pathway as well as the canonical Wnt signaling pathway. Although both pathways require a …

Corin is a type II transmembrane serine protease and functions as the proatrial natriuretic
peptide (pro-ANP) convertase in the heart. In the extracellular region of corin, there are two …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

During Caenorhabditis elegans development, the HSN neurons and the right Q neuroblast
and its descendants undergo long-range anteriorly directed migrations. Both of these …

In higher vertebrates, the paraxial mesoderm undergoes a mesenchymal to epithelial
transformation to form segmentally organised structures called somites. Experiments have …