The role of endogenous kinins and their receptors in diabetes mellitus is being confirmed
with the recent developments of molecular and genetic animal models. Compelling …

Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine
proteases. Two distinct kinin receptors have been described, one constitutive (subtype B2) …

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in
arterial hypertension has showed that these molecules can exert beneficial effects on insulin …

Insulin-dependent diabetes mellitus (type 1 diabetes) is an inflammatory autoimmune
disease associated with vascular permeability changes leading to many complications …

Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-
Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are …

Insulin-dependent diabetes mellitus (type-1 diabetes) is an inflammatory autoimmune
disease associated with vascular permeability changes leading to many complications …

Abstract Both insulin-dependent (type 1) and insulin-independent (type 2) diabetes are
complex disorders characterized by symptomatic glucose intolerance due to either defective …

Cardiac ischemia is a leading cause of death, especially in diabetic patients. The diabetic
ischemic heart is resistant experimentally to established cardioprotective treatments. New …

This review addresses the physiological role of the kallikrein–kinin system in arteries, heart
and kidney and the consequences of kallikrein and kinin actions in diseases affecting these …

Kinins are synthesized from their precursors by different enzymes and participate in the
regulation of cardiovascular function through bradykinin (BK) B1 and B2 receptors. They …