Biopharmaceutics classification by high throughput solubility assay and PAMPA
K Obata, K Sugano, M Machida… - Drug development and …, 2004 - Taylor & Francis
The purpose of the present study was to examine the relevancy of the high throughput
solubility assay and permeability assay to the biopharmaceutics classification system (BCS) …
solubility assay and permeability assay to the biopharmaceutics classification system (BCS) …
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery
MV Varma, I Gardner, SJ Steyn, P Nkansah… - Molecular …, 2012 - ACS Publications
The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
Application of method suitability for drug permeability classification
DA Volpe - The AAPS journal, 2010 - Springer
Experimental models of permeability in animals, excised tissues, cell monolayers, and
artificial membranes are important during drug discovery and development as permeability …
artificial membranes are important during drug discovery and development as permeability …
An improved prediction of the human in vivo intestinal permeability and BCS class of drugs using the in vitro permeability ratio obtained for rat intestine using an …
H Li, HE Jin, WS Shim, CK Shim - Drug development and industrial …, 2013 - Taylor & Francis
The Biopharmaceutics Classification System (BCS) was developed to facilitate estimation of
the in vivo pharmacokinetic performance of drugs from human intestinal permeability and …
the in vivo pharmacokinetic performance of drugs from human intestinal permeability and …
The utility of rat jejunal permeability for biopharmaceutics classification system
P Zakeri-Milani, H Valizadeh… - Drug development …, 2009 - Taylor & Francis
Purpose: The biopharmaceutical classification system has been developed to provide a
scientific approach for classifying drug compounds based on their dose/solubility ratio and …
scientific approach for classifying drug compounds based on their dose/solubility ratio and …
Drug permeability-best practices for Biopharmaceutics Classification System (BCS)-based biowaivers: a workshop summary report
M Mehta, JE Polli, P Seo, S Bhoopathy… - Journal of …, 2023 - Elsevier
Abstract The workshop “Drug Permeability-Best Practices for Biopharmaceutics
Classification System (BCS) Based Biowaivers” was held virtually on December 6, 2021 …
Classification System (BCS) Based Biowaivers” was held virtually on December 6, 2021 …
The use of drug metabolism for prediction of intestinal permeability
ML Chen, L Yu - Molecular pharmaceutics, 2009 - ACS Publications
The Biopharmaceutics Classification System (BCS), based on the aqueous solubility and
intestinal permeability of a drug substance, has been widely used to predict the extent of …
intestinal permeability of a drug substance, has been widely used to predict the extent of …
Integrating theoretical and experimental permeability estimations for provisional biopharmaceutical classification: Application to the WHO essential medicines
MÁ Cabrera‐Pérez, H Pham‐The… - … & Drug Disposition, 2018 - Wiley Online Library
The accuracy of the provisional estimation of the Biopharmaceutics Classification System
(BCS) is heavily influenced by the permeability measurement. In this study, several …
(BCS) is heavily influenced by the permeability measurement. In this study, several …
Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay
VE Thiel-Demby, JE Humphreys… - Molecular …, 2009 - ACS Publications
The Biopharmaceutics Classification System (BCS) is the scientific basis for classifying
drugs based on their aqueous solubility and intestinal permeability that supports in vivo …
drugs based on their aqueous solubility and intestinal permeability that supports in vivo …
Quantitative biopharmaceutics classification system: the central role of dose/solubility ratio
E Rinaki, G Valsami, P Macheras - Pharmaceutical research, 2003 - Springer
Purpose. To develop a quantitative biopharmaceutics drug classification system (QBCS)
based on fundamental parameters controlling rate and extent of absorption. Methods. A …
based on fundamental parameters controlling rate and extent of absorption. Methods. A …