Addiction can be viewed as a form of drug-induced neural plasticity. One of the best-
established molecular mechanisms of addiction is upregulation of the cAMP second …

Addiction can be viewed as a form of drug-induced neural plasticity. One of the best
established molecular mechanisms of addiction is the upregulation of the cAMP second …

Regulation of gene expression is one mechanism by which drugs of abuse can induce
relatively long-lasting changes in the brain to cause a state of addiction. Here, we focus on …

Regulation of gene expression is considered a plausible mechanism of drug addiction given
the stability of behavioral abnormalities that define an addicted state. Numerous …

Cocaine produces its psychoactive and addictive effects primarily by acting on the brain's
limbic system, a set of interconnected regions that regulate pleasure and motivation. An …

The transcription factor ΔFosB is upregulated in numerous brain regions following repeated
drug exposure. This induction is likely to, at least in part, be responsible for the mechanisms …

Despite staggering advances in the neurosciences over the past decade, detailed
knowledge of the pathophysiology and pathogenesis of psychiatric disorders remains …

Drug addiction has afflicted mankind for centuries, yet the mechanisms by which particular
drugs lead to addiction, and the genetic factors that make some individuals particularly …

The longevity of some of the behavioral abnormalities that characterize drug addiction has
suggested that regulation of neural gene expression may be involved in the process by …

Chronic administration of opiates or cocaine has been shown to alter the activity or
expression of diverse types of cellular proteins in specific target neurons within the central …