The region of conserved synteny on mouse chromosome 11/human 17q11–q21 is known to
carry a susceptibility gene (s) for intramacrophage pathogens. The region is rich in …

Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage
1, 405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 …

Leprosy is a complex disease with phenotypes strongly influenced by genetic variation. A
Chinese genome-wide association study (GWAS) depicted novel genes and pathways …

We combined two tuberculosis genome-wide association studies from Ghana and The
Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located …

Chromosome 17 is known to contain TB susceptibility genes. Polymorphisms in two of these
genes, namely NOS2A and CCL2, have been associated with TB in various populations. To …

Host genetics plays an important role in individual susceptibility and resistance to infectious
diseases, but no genes have yet been identified using genome-wide screens. Twin studies …

In Mycobacterium tuberculosis (MTB) infection, the complex interaction of host immune
system and the mycobacteria is associated with levels of cytokines production that play a …

OBJECTIVE: To determine whether cytokine polymorphisms are associated with leprosy
and/or their subtypes in a Brazilian population. METHODS: Genotyping using polymerase …

Immunosuppression resulting from HIV infection increases the risk of progression to active
tuberculosis (TB) both in individuals newly exposed to Mycobacterium tuberculosis (MTB) …

Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will
develop active tuberculosis (TB). Approximately half will progress to active TB within the first …