Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology

T Teaktong, AJ Graham, JA Court, RH Perry… - Journal of the …, 2004 - Elsevier
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly. The neuropathology of AD and DLB is related to cholinergic …

Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes

T Teaktong, A Graham, J Court, R Perry, E Jaros… - Glia, 2003 - Wiley Online Library
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly associated with cholinergic dysfunction, including reductions in …

Nicotinic receptor losses in dementia with Lewy bodies: comparisons with Alzheimer's disease

RT Reid, MN Sabbagh, J Corey–Bloom… - Neurobiology of …, 2000 - Elsevier
We sought to delineate differences between α7 nicotinic acetylcholine receptor (nAChR)
levels in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and age matched …

Cortical α7 nicotinic acetylcholine receptor and β-amyloid levels in early Alzheimer disease

MD Ikonomovic, L Wecker, EE Abrahamson… - Archives of …, 2009 - jamanetwork.com
Objective To examine α7 nicotinic acetylcholine receptor (nAChR) binding and β-amyloid
(Aβ) peptide load in superior frontal cortex (SFC) across clinical and neuropathological …

Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies

MN Sabbagh, RT Reid, LA Hansen, M Alford… - Journal of neural …, 2001 - Springer
We investigated the relationship between the loss of nicotinic acetylcholine receptors
(nAChR) and the cognitive decline or neuropathological changes seen in Alzheimer's …

Involvement of α6/α3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies:[125I]-α-conotoxin MII binding in the …

M Ray, I Bohr, JM McIntosh, C Ballard, I McKeith… - Neuroscience …, 2004 - Elsevier
Dementia with Lewy bodies (DLB) is a neurodegenerative disease associated with a range
of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine …

Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies

H Fujishiro, H Umegaki, D Isojima, H Akatsu… - Acta …, 2006 - Springer
The cholinergic basal forebrain is divided into four subregions (Ch1–4), and cholinergic
neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive …

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and …

A Wevers, L Monteggia, S Nowacki… - European Journal of …, 1999 - Wiley Online Library
Impairment of cholinergic transmission and decreased numbers of nicotinic binding sites are
well‐known features accompanying the cognitive dysfunction seen in Alzheimer's disease …

Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β …

J Xiu, A Nordberg, JT Zhang, ZZ Guan - Neurochemistry international, 2005 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are thought to be involved in the
pathogenesis of Alzheimer's disease (AD). Interestingly, in the brains of patients with this …

Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications

A Nordberg - Biological psychiatry, 2001 - Elsevier
The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for
functional processes, including cognitive and memory functions. The nAChRs acting as …