Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology
T Teaktong, AJ Graham, JA Court, RH Perry… - Journal of the …, 2004 - Elsevier
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly. The neuropathology of AD and DLB is related to cholinergic …
dementia in the elderly. The neuropathology of AD and DLB is related to cholinergic …
Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
T Teaktong, A Graham, J Court, R Perry, E Jaros… - Glia, 2003 - Wiley Online Library
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly associated with cholinergic dysfunction, including reductions in …
dementia in the elderly associated with cholinergic dysfunction, including reductions in …
Nicotinic receptor losses in dementia with Lewy bodies: comparisons with Alzheimer's disease
RT Reid, MN Sabbagh, J Corey–Bloom… - Neurobiology of …, 2000 - Elsevier
We sought to delineate differences between α7 nicotinic acetylcholine receptor (nAChR)
levels in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and age matched …
levels in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and age matched …
Cortical α7 nicotinic acetylcholine receptor and β-amyloid levels in early Alzheimer disease
MD Ikonomovic, L Wecker, EE Abrahamson… - Archives of …, 2009 - jamanetwork.com
Objective To examine α7 nicotinic acetylcholine receptor (nAChR) binding and β-amyloid
(Aβ) peptide load in superior frontal cortex (SFC) across clinical and neuropathological …
(Aβ) peptide load in superior frontal cortex (SFC) across clinical and neuropathological …
Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies
MN Sabbagh, RT Reid, LA Hansen, M Alford… - Journal of neural …, 2001 - Springer
We investigated the relationship between the loss of nicotinic acetylcholine receptors
(nAChR) and the cognitive decline or neuropathological changes seen in Alzheimer's …
(nAChR) and the cognitive decline or neuropathological changes seen in Alzheimer's …
Involvement of α6/α3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies:[125I]-α-conotoxin MII binding in the …
Dementia with Lewy bodies (DLB) is a neurodegenerative disease associated with a range
of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine …
of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine …
Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies
H Fujishiro, H Umegaki, D Isojima, H Akatsu… - Acta …, 2006 - Springer
The cholinergic basal forebrain is divided into four subregions (Ch1–4), and cholinergic
neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive …
neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive …
Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and …
A Wevers, L Monteggia, S Nowacki… - European Journal of …, 1999 - Wiley Online Library
Impairment of cholinergic transmission and decreased numbers of nicotinic binding sites are
well‐known features accompanying the cognitive dysfunction seen in Alzheimer's disease …
well‐known features accompanying the cognitive dysfunction seen in Alzheimer's disease …
Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β …
J Xiu, A Nordberg, JT Zhang, ZZ Guan - Neurochemistry international, 2005 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are thought to be involved in the
pathogenesis of Alzheimer's disease (AD). Interestingly, in the brains of patients with this …
pathogenesis of Alzheimer's disease (AD). Interestingly, in the brains of patients with this …
Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications
A Nordberg - Biological psychiatry, 2001 - Elsevier
The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for
functional processes, including cognitive and memory functions. The nAChRs acting as …
functional processes, including cognitive and memory functions. The nAChRs acting as …
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