Several studies have now clearly established the ability of LPS to induce bradykinin B 1
receptor up-regulation in vivo and the functional relevance of this up-regulation for the …

It has been demonstrated that kinin B1 receptors are highly up-regulated under several
stressful stimuli, such as infection. However, there is no evidence indicating whether …

We demonstrated that rat kinin B 1 receptors displayed a ligand-independent constitutive
activity, assessed through inositol phosphate production in transiently or stably transfected …

Expression of the bradykinin B 1 receptor gene is up-regulated in vascular smooth muscle
cells (VSMCs) in response to a variety of inflammatory stimuli. We isolated the 5′-flanking …

The present study examines the role of migrating leukocytes in the ability of IL‐1β to induce
the functional up‐regulation of B1 receptors, as assessed by kinin B1 agonist‐induced …

Kinin B1 receptor expression was characterized in human umbilical artery smooth muscle
cells to further elucidate the function and specificity of three previously proposed pathways …

B1 kinin receptor (B1R) is up-regulated by endotoxins and thus may represent a therapeutic
target in sepsis. We investigated the expression and role of B1R and B2R in the acute phase …

Several cytokines and LPS regulate the population of the B 1 receptors (B 1 Rs) for kinins;
these are responsive to des-Arg 9-bradykinin (BK) and Lys-des-Arg 9-BK. B 1 R activation …

Intradermal (id) injection of cytokines, IL‐1β and TNFα (5 ng, 60 and 30 min prior) produces
a rapid onset up‐regulation of des‐Arg9‐BK‐mediated rat paw oedema. Here we analyse …

Bradykinin B1 receptor (BKB1R) is involved in a variety of pathophysiological processes,
particularly those related to inflammation. The gene for this receptor is known to be …