Glutathione peroxidase is one of the principal antioxidant defense enzymes in human
spermatozoa, but it requires oxidized glutathione to be reduced by glutathione reductase …

In order to characterize further the antilipoperoxidative enzyme system of human sperm, that
part of the system designed to provide reducing equivalents for the reduction of highly …

The ejaculated spermatozoon, as an aerobic cell, must fight against toxic levels of reactive
oxygen species (ROS) generated by its own metabolism but also by other sources such as …

In mammals, posttesticular epididymal sperm maturation is considered an essential step in
the transformation of immature testicular gametes to mature spermatozoa capable of …

The cellular generation of reactive oxygen species was first observed in mammalian
spermatozoa in the late 1940s. The field then remained dormant for 30 years until Thaddeus …

Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These
gametes are professional generators of reactive oxygen species (ROS), which appear to …

Recent studies have demonstrated that human spermatozoa are capable of generating
reactive oxygen species and that this activity is significantly accelerated in cases of defective …

Mouse and human spermatozoa, but not rabbit spermatozoa, have long been known to be
sensitive to loss of motility induced by exogenous H2O2. Recent work has shown that loss of …

1422 potential, such as superoxide radicals (O2–), hydrogen peroxide (H2O2) and the
hydroxyl radical (OH–), can result in peroxidative damage to the cell lipid membranes …

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx, EC 1.11.
1.12) is present, in both free and membrane-bound form, in several mammalian tissues. It …