HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We
show that HLA polymorphism also controls the choice of Ag presentation pathway. A single …

Major histocompatibility complex class I (MHC-I) molecules present antigenic peptides to
CD8+ T cells, and are also important for natural killer (NK) cell immune surveillance against …

The high diversity of HLA binding preferences has been driven by the sequence diversity of
short segments of relevant pathogenic proteins presented by HLA molecules to the immune …

Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …

Class I HLAs generally present peptides of 8–10 aa in length, although it is unclear whether
peptide length preferences are affected by HLA polymorphism. In this study, we investigated …

Stable cell surface presentation of HLA class I molecules requires active transport of
antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and …

Central players of the adaptive immune system are the groups of proteins encoded in the
major histocompatibility complex (MHC), which shape the immune response against …

MHC class I ligands are recruited from the cytosolic peptide pool, whose size is likely to
depend on the balance between peptide generation by the proteasome and peptide …

Tapasin is a resident ER protein believed to be critical for antigen presentation by HLA class
I molecules. We demonstrate that allelic variation in MHC class I molecules influences their …

The highly polymorphic genes of the major histocompatibility complex (MHC) play a key role
in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is …