The random and inherently imprecise process of V (D) J recombination is the foundation for
generation of the B-cell receptor (BCR). Signals must be generated to trigger selective …

Signal transduction through the B cell antigen receptor (BCR) is determined by a balance of
positive and negative regulators. This balance is shifted by aggregation that results from …

Expression of clonotypic antigen receptors (AgR) on lymphocytes is required for vertebrates
to combat foreign antigens. Since somatic rearrangement ofthe receptor genes and …

The B-cell antigen receptor (BCR) is one of the most abundant receptors on the surface of B
cells with roughly 100,000–200,000 copies per cell. Signaling through the BCR is crucial for …

In lymphocytes, DNA recombinations that generate the antigen-receptor genes can
sometimes be reinduced in receptor-bearing cells in a process called receptor editing, which …

B‐cell development is a highly ordered multistep process dependent upon signals
generated by the pre‐B and B‐cell antigen receptor (BCR). BCR signals drive maturation of …

The majority of early immature B cells express autoreactive B cell receptors (BCRs) that are,
according to the current view, negatively selected to avoid the production of self-reactive …

B cells are selected by the binding of antigen to clonally distributed B cell receptors (BCRs),
triggering signalling cascades that result in B cell activation. With the recent application of …

Blymphocytes RESPOND TO numerous stimuli that regulate development, negative
selection in the bone marrow, activation, proliferation and the generation of humoral immune …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …