Neonatal Network ONAATA TL Net W in the newborn). Cafcit®(commercial caffeine citrate),
is a preservative-free citrate salt in solution with citric acid. Each 20 mg of Cafcit® contains …

Background: Irregularity in temperature regulation and control of breathing during the first
few days are the reasons for the abrupt deaths in preterm neonates, of which apnea in …

Considerable uncertainty persists regarding the efficacy and safety of methylxanthines
(caffeine, theophylline–in intravenous form named aminophylline) for the prevention and …

Background Considerable interindividual variability for the pharmacokinetics of caffeine in
preterm infants has been demonstrated, emphasizing the importance of personalized …

Caffeine has become one of the most prescribed drugs in neonatal medicine. 1-3 The effects
of this medication on mortality, neonatal morbidities, and child development have been …

The decision-making process for estimating the optimal dosage is critical in clinical settings.
In the neonatal intensive care unit (NICU), preterm neonates suffering from apnea of …

Caffeine and other methylxanthines have been used to treat apnoea of prematurity for over
30 years. However, until recently, experimental evidence of the potential harm and lack of …

Caffeine citrate is one of the most prescribed drug in the present day NICU for apnea. Its
efficacy, tolerability, wide therapeutic index and safety margin has made it the drug of choice …

Background Caffeine has been extensively used in the treatment of apnoea in premature
infants, 1 its disposition varies with postnatal age 2 and can differ markedly between …