When dissolution testing is used to forecast the in vivo performance of a drug, it is critical that
the in vitro test mimic the conditions in vivo as closely as possible. A team of researchers, led …

Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

Purpose The aim of this study was to update the compositions of biorelevant media to
represent the composition and physical chemical characteristics of the gastrointestinal fluids …

Dissolution tests that can predict the in vivo performance of drug products are usually called
biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide …

The use of compendial dissolution techniques to characterize the performance of oral drug
delivery systems is an established area of pharmaceutical science. However, compendial …

Many pharmacologically active molecules are formulated as solid dosage form drug
products. Following oral administration, the diffusion of an active molecule from the …

Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of poorly soluble drugs. Simulating small intestinal conditions with biorelevant …

In line with the key focus of recent publications1-3 emerging from the labs of Dressman,
Amidon, and Shah, and in conjunction with the aims of both the FDA and US …

Dissolution testing can play an important role in several areas for drug products as a quality
control tool to monitor batch-to-batch consistency of drug release from a dosage form and as …

Pharmaceutical solid oral dosage forms must undergo dissolution in the intestinal fluids of
the gastrointestinal tract before they can be absorbed and reach the systemic circulation …