Due to their ability to gain access to target cell genomes without mitosis-related dissolution
of the nuclear membrane, lentiviral vectors are useful tools for the genetic modification of …

Our goal is to develop cell vaccines against leukemia cells, genetically modified to express
molecules with potent immune-stimulatory capacities. Pre-clinical evaluation of this …

Gene therapy of many genetic diseases requires permanent gene transfer into self-renewing
stem cells and restriction of transgene expression to specific progenies. Human …

Lentiviral vectors are promising tools for the development of gene therapy since they can
transduce both quiescent and dividing target cells. Lentiviral vectors may be particularly …

Lentiviral vectors are more efficient at transducing quiescent hematopoietic stem cells than
murine retroviral vectors. This characteristic is due to multiple karyophilic components of the …

Publisher Summary This chapter discusses lentiviral vectors design and function and
discusses recent advances that improve their biosafety and demonstrate their potential for …

Cell vaccines engineered to express immunomodulators have shown feasibility in
eliminating leukemia in murine models. Vectors for efficient gene delivery to primary human …

Correction of blood genetic disorders requires permanent gene transfer into self renewing,
hematopoietic stem cells (HSC), and regulation of transgene expression in specific cell …

The present invention provides HIV-derived lentivectors which are safe, highly efficient, and
very potent for express ing transgenes for human gene therapy, especially, in human …

The present invention provides HIV-derived lentivectors which are safe, highly efficient, and
very potent for express ing transgenes for human gene therapy, especially, in human …