N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?

J Delarue, C LeFoll, C Corporeau… - Reproduction nutrition …, 2004 - rnd.edpsciences.org
n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), mainly eicosapentaenoic acid
(EPA, 20: 5 n-3) and docosahexaenoic acid (DHA, 22: 6 n-3), are present in mammal tissues …

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

YB Lombardo, AG Chicco - The Journal of nutritional biochemistry, 2006 - Elsevier
For many years, clinical and animal studies on polyunsaturated n-3 fatty acids (PUFAs),
especially those from marine oil, eicosapentaenoic acid (20: 5, n-3) and docosahexaenoic …

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator–activated receptor-α–dependent manner

S Neschen, K Morino, J Dong, Y Wang-Fischer… - Diabetes, 2007 - Am Diabetes Assoc
Recent studies have suggested that n-3 fatty acids, abundant in fish oil, protect against high-
fat diet–induced insulin resistance through peroxisome proliferator–activated receptor …

Conversion of -linolenic acid to longer-chain polyunsaturated fatty acids in human adults

GC Burdge, PC Calder - Reproduction Nutrition Development, 2005 - rnd.edpsciences.org
The principal biological role of $\alpha $-linolenic acid ($\alpha $ LNA; 18: 3n-3) appears to
be as a precursor for the synthesis of longer chain n-3 polyunsaturated fatty acids (PUFA) …

Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids

M Bhaswant, H Poudyal, L Brown - The Journal of nutritional biochemistry, 2015 - Elsevier
The widespread acceptance that increased dietary n-3 polyunsaturated fatty acids (PUFAs),
especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid …

DHA-enriched fish oil reduces insulin resistance in overweight and obese adults

KA Abbott, TL Burrows, S Acharya, RN Thota… - … and Essential Fatty …, 2020 - Elsevier
Adipose tissue inflammation is major factor in the development of insulin resistance (IR).
Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) docosahexaenoic acid …

[HTML][HTML] Insulin-sensitizing effects of omega-3 fatty acids: lost in translation?

AZ Lalia, IR Lanza - Nutrients, 2016 - mdpi.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA) of marine origin, eicosapentaenoic acid
(EPA), and docosahexaenoic acid (DHA), have been long studied for their therapeutic …

[HTML][HTML] Treatment for 2 mo with n− 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women …

M Kabir, G Skurnik, N Naour, V Pechtner… - The American journal of …, 2007 - Elsevier
Background: Information is lacking on the potential effect of n− 3 polyunsaturated fatty acids
(PUFAs) on the adipose tissue of patients with type 2 diabetes. Objective: We evaluated …

Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet

AR Martins, AR Crisma, LN Masi, CL Amaral… - The journal of nutritional …, 2018 - Elsevier
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …

Temporal changes in dietary fats: role of n− 6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity

G Ailhaud, F Massiera, P Weill, P Legrand… - Progress in lipid …, 2006 - Elsevier
The importance of a high fat intake in the increasing prevalence of childhood and adult
obesity remains controversial. Moreover, qualitative changes (ie the fatty acid composition of …