Cannabinoids are well known for their effects on neurotransmission in the central nervous
system. Whereas the components of cannabinoid signaling have been intensively studied in …

This chapter collects all the preclinical and clinical evidence, which supports the idea that
cannabinoids deserve to be investigated, as well as that on‐going cannabinoid‐based …

In the last few years the role and significance of the glia in CNS function and pathology have
been drastically reassessed. Glial cells physiology appears very different in healthy versus …

The cannabinoid signaling system is composed of cannabinoid (CB) receptors, their
endogenous ligands, the endocannabinoids, and the enzymes that produce and inactivate …

The discovery of cannabinoid receptors as the primary molecular targets of psychotropic
cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for …

Multiple lines of evidence indicate a prominent role for the cannabinoid signaling system in
the control of basal ganglia function, exerted by modulating the activity of various classic …

The study of the astrocytic contribution to brain functions has been growing in popularity in
the neuroscience field. In the last years, and especially since the demonstration of the …

The endocannabinoid system participates in the regulation of CNS homeostasis and
functions, including neurotransmission, cell signaling, inflammation and oxidative stress, as …

The endocannabinoid system exerts an important neuromodulatory function in different
brain areas and is also known to be involved in the regulation of neural cell fate. Thus, CB1 …

The endocannabinoid system is widely expressed both in the brain and in the periphery.
This system regulates a plethora of physiological functions and is composed of cannabinoid …