Considerable evidence suggests that neuroadaptations leading to addiction involve the
same glutamate-dependent cellular mechanisms that enable learning and memory. Long …

Addiction is believed to involve glutamate-dependent forms of synaptic plasticity that
promote the formation of new habits focused on drug seeking. We used primary cultures of …

Considerable evidence indicates that neuroadaptations leading to addiction involve the
same cellular processes that enable learning and memory, such as long‐term potentiation …

Long-term changes in the efficacy of glutamatergic synaptic transmission in the striatal
complex are proposed to underlie motor learning and neuroadaptations leading to …

While dopamine (DA) receptors mediate acute effects of amphetamine and cocaine, chronic
drug administration produces many glutamate‐dependent adaptations, including LTP in …

Recent studies have suggested that the development of addictive behaviours shares
common features with traditional learning models. Synaptic plasticity, a possible substrate …

Experience-dependent changes in synaptic strength, or synaptic plasticity, may underlie
many learning processes. In the reward circuit for example, synaptic plasticity may serve as …

Synaptic plasticity in the ventral tegmental area (VTA) has been implicated in the acquisition
of a drug-dependent state. Even a single exposure to cocaine in naive animals is sufficient …

The mesolimbic dopamine system is essential for reward‐seeking behavior, and drugs of
abuse perturb the normal functioning of this pathway. The nucleus accumbens (NAc) is a …

There is a high degree of overlap between brain regions involved in processing natural
rewards and drugs of abuse.“Non-drug” or “behavioral” addictions have become …