Twenty-five years ago the first human, Louise Brown, was conceived outside the body, and
this event created a new milestone in the history of mankind and the concept of human in …

Reactive oxygen species (ROS) are involved in physiological functions and act as mediators
in various signaling processes. Elevated or sustained generation of free radicals and non …

Infertility is a common problem experienced by many couples. Numerous treatments are
available for female infertility. However, in some cases, the treatment is empirical in nature …

Assisted reproductive technology (ART) is a common treatment of choice for many couples
facing infertility issues, be it due to male or female factor, or idiopathic. Employment of ART …

Reactive oxygen species (ROS) have a role in the modulation of gamete quality and gamete
interaction. Generation of ROS is inherent in spermatozoa and contaminating leukocytes …

Oxidative stress has been implicated in male and female infertility, including fetal
dysmorphogenesis, abortions, and intrauterine growth restriction. Accurate evaluation of …

The spermatozoon is a highly specialized cell, whose main function is the transport of the
intact male genetic material into the oocyte. During its formation and transit throughout male …

One of the major causes of defective sperm function is oxidative stress, which not only
disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a …

Gametes and embryos are natural sources of free radicals. When manipulated in vitro during
assisted reproductive techniques, these cells run the risk of generating and being exposed …

Extensive research in our center at the Cleveland Clinic indicates that the seminal oxidative
stress test has diagnostic and prognostic capabilities beyond those of conventional tests of …