Zinc is an essential nutrient for all organisms. Its requirement in humans is illustrated
dramatically by the genetic disorder acrodermatitis enteropathica (AE). AE is caused by the …

The mouse mZip1 and mZip3 zinc transporters have been implicated in zinc acquisition by
the cells of many tissues. This hypothesis raised the question of whether activity of these …

The mouse and human Zip5 proteins are members of the ZIP family of metal ion
transporters. In this study, we present evidence that mouse Zip5 is a zinc uptake transporter …

Zinc is the second most abundant transition metal in the body. Despite the fact that hundreds
of biomolecules require zinc for proper function and/or structure, the mechanism of zinc …

Zinc is an essential metal for all eukaryotes, and cells have evolved a complex system of
proteins to maintain the precise balance of zinc uptake, intracellular storage, and efflux. In …

Zinc is an essential nutrient. Genetic evidence for this nutritional requirement in humans is
the zinc deficiency disease, acrodermatitis enteropathica. This disorder is caused by …

The ZIP superfamily of transporters plays important roles in metal ion uptake in diverse
organisms. There are 12 ZIP-encoding genes in humans, and we hypothesize that many of …

The Zip4 protein is involved in dietary zinc uptake from the intestinal lumen. The human ZIP4
gene (SLC39A4) was identified because of its association with acrodermatitis enteropathica …

Dietary zinc deficiency in mice is accompanied by enhanced expression of the zinc uptake
transporter Slc39a4 (Zip4) and repressed expression of Slc39a5 (Zip5) in tissues which …

The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism
acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the …