Background & Aims: Gap junctional communication was studied in quiescent and activated
hepatic stellate cells. Methods: Connexin expression and intercellular dye transfer were …

Oculodentodigital dysplasia (ODDD) is associated with at least 28 connexin43 (Cx43)
mutations. We characterized four of these mutants; Q49K, L90V, R202H, and V216L …

Gap junctions, which are essential for functional coordination and homeostasis within
tissues, permit the direct intercellular exchange of small molecules. The abundance and …

Gap junctions are clusters of intercellular channels that provide morphological support for
direct diffusion of ions and low-molecular-weight molecules between adjacent coupled cells …

A histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induces
apoptosis in neoplastic cells, but its effect on gap junctional intercellular communication in …

Since carcinogenesis is a multi-stage, multi-mechanism process, involving mutagenic, cell
death and epigenetic mechanisms, during the “initiation/promotion/and progression” …

Background: Gap junctional intercellular communication (GJIC) is a mechanism for direct
cell-to-cell signalling and is mediated by gap junctions, which consist of transmembrane …

Objective: Fibroblasts have been shown to couple to neonatal cardiomyocytes in
heterocellular cultures through functional gap junctions. Our objective was to provide …

Haploinsufficiency of T-box transcription factor 5 (TBX5) causes human Holt-Oram syndrome
(HOS), a developmental disorder characterized by skeletal and heart malformations. Mice …

purpose. Keratocytes are connected to each other by gap junctions, which mediate
intercellular communication and contribute to maintenance of corneal homeostasis. The …