Cell organization is largely orchestrated by extracellular gradients of morphogenetic
proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular …

Convective transport can significantly distort spatial concentration gradients. Interstitial flow
is ubiquitous throughout living tissue, but our understanding of how interstitial flow affects …

Capillary morphogenesis is a crucial angiogenic response of endothelial cells. Although
fibroblast growth factor-2 (FGF-2) potently induces capillary morphogenesis, the contribution …

Physical forces play a major role in the organization of developing tissues. During vascular
development, physical forces originating from a fluid phase or from cells pulling on their …

The function of a tissue depends upon the spatial arrangement of its constituent cells. But
control of morphogenesis, the process by which spatial arrangement arises, is poorly …

We show here that autocrine ligand activation of epidermal growth factor (EGF) receptor in
combination with interstitial flow is critically involved in the morphogenetic response of …

In vitro endothelial cell organization into capillaries is a long standing challenge of tissue
engineering. We recently showed the utility of low level interstitial flow in guiding the …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Development of tissues in vitro with dimensions larger than 150 to 200 μm requires the
presence of a functional vascular network. Therefore, we have studied capillary …

Background Blood vessels comprise endothelial cells, mural cells (pericytes/vascular
smooth muscle cells) and basement membrane. During angiogenesis, mural cells are …