Beta-adrenergic receptors and the cyclic AMP signaling pathway play an important role in
neuronal plasticity and in learning and memory and are known to change with aging. We …

Adenylyl cyclase (AC) subtypes have been implicated in memory processes and synaptic
plasticity. In the present study, the effects of aging and learning on Ca2+/calmodulin …

Recent studies suggest that increases in intracellular cAMP increase evoked synaptic
responses in area CA1 of the hippocampus. We recently reported that activation of …

The cellular mechanisms underlying beta-adrenergic potentiation in the CA1 region of the
rat hippocampus were examined. A 10 min treatment with isoproterenol (ISO) induced a …

Memory loss in humans begins early in adult life and progresses thereafter. It is not known
whether these losses reflect the failure of cellular processes that encode memory or …

Ca2+-stimulated adenylyl cyclases are important for several forms of neuroplasticity
because they couple activity-dependent Ca2+ increases to cAMP in neurons. For example …

There is significant interest in understanding the contribution of intracellular signaling and
synaptic substrates to memory flexibility, which involves new learning and suppression of …

Neuromodulation by means of the catecholaminergic system is a key component of
motivation-driven learning and behaviorally modulated hippocampal synaptic plasticity. In …

Recent evidence shows a greater facilitating effect of beta-adrenergic receptors (β-ARs) on
long-term synaptic plasticity in the ventral versus the dorsal hippocampus. Here, using field …

Impaired regulation of intracellular calcium is thought to adversely affect synaptic plasticity
and cognition in the aged brain. Comparing young (2–3 months) and aged (23–26 months) …