There are three connected molecular mechanisms of epigenetic cellular memory in
mammalian cells: DNA methylation, histone modifications, and RNA interference. The first …

The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

Transcriptional silencing resulting from changes in epigenetic regulation of gene expression
is the most frequent mechanism by which tumor suppressor genes are inactivated in human …

The cancer epigenome is characterized by global DNA methylation and chromatin changes,
such as the hypermethylation of specific CpG island promoters. Epigenetic agents like DNA …

CpG islands are associated with at least half of all cellular genes and are normally
methylation-free. Dense methylation of cytosine residues within islands causes strong and …

Epigenetic modifications are defined as heritable changes in gene activity that do not
involve changes in the underlying DNA sequence. The oncogenic process is driven by the …

Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

The DNA methylation profile of cancer cells is frequently characterized by global
hypomethylation and simultaneous hypermethylation of selected CpG island gene …

Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer.
Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological …