Background The majority of patients with advanced urothelial cancer are elderly, but data
regarding this specific age group are limited. We compared the tolerability and efficacy of …

Purpose Cisplatin-based chemotherapy is standard first-line treatment for metastatic
urothelial carcinoma. However, cisplatin is frequently avoided in elderly patients due to …

Objective: We evaluated safety and efficacy of first-line gemcitabine/carboplatin in unfit-for-
cisplatin patients with advanced urothelial carcinoma and the effect on the quality of life and …

Strategies to improve cancer care in the field of urothelial carcinoma (UC) in the elderly or in
patients unfit to receive cisplatin treatment are urgently needed. This effort requires …

Background Renal dysfunction, poor performance status, and comorbidities may preclude
frontline cisplatin-based chemotherapy in patients with advanced urothelial carcinoma (UC) …

Purpose Although cisplatin-based chemotherapy is the standard of care for advanced
transitional cell carcinoma, tolerability is a challenging issue in unfit patients. This study was …

Objective: The efficacy of second-line treatment after failure of platinum-based
chemotherapy in patients with advanced urothelial cancer is limited. Based on encouraging …

Purpose: We evaluated the impact of the number of cycles of platinum based, first line
chemotherapy (fewer than 6 cycles vs the conventional 6 cycles or more) on the survival of …

Background We evaluated retrospectively the feasibility and effectiveness of carboplatin-
based combination chemotherapy in elderly patients with advanced bladder cancer …

OBJECTIVES: To evaluate, in a multicenter Phase II study, the safety and efficacy of the
combination of gemcitabine and carboplatin, as first-line treatment in elderly and unfit …