Background & Aims: Recently, an alternative pathway of tumorigenesis has been identified
in the colorectum associated with serrated precursor lesions, variable levels of microsatellite …

The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of
these BRAF mutant cancers demonstrate frequent frameshift mutations termed microsatellite …

BACKGROUND Alterations of BRAF have been implicated in the carcinogenesis of
colorectal tumors with microsatellite instability (MSI). These alterations were attributed to …

Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC)
showing high level microsatellite instability (MSI-H). However, the distribution of BRAF …

BACKGROUND: Colorectal cancer is a heterogeneous disease with multiple underlying
genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a …

The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …

The BRAF gene is mutated in 4% to 12% of unselected colorectal cancers, particularly those
with high microsatellite instability and in premalignant lesions, such as serrated adenomas …

There is increasing evidence for an alternative pathway of sporadic colorectal
tumourigenesis that is associated with DNA microsatellite instability (MSI), due to …

Abstract Background and Aims Between 10 and 15% of all cases of colorectal cancer are
the result of microsatellite instability (MSI) in the genetic pathway due to an alteration in the …

The BRAF mutations have been suggested to be linked with defective mismatch repair in
colorectal carcinomas. To clarify the extent of BRAF mutations in HNPCC colorectal …