Behavioral sensitization is the augmented motor-stimulant response that occurs with
repeated, intermittent exposure to most drugs of abuse, including cocaine. Sensitization …

Repeated exposure to psychostimulants such as cocaine and amphetamine produces
behavioral sensitization, which is characterized by an augmented locomotor response to a …

Studies support the involvement of mPFC dopaminergic and glutamatergic systems in the
development of cocaine sensitization. GABA is known to modulate dopamine and …

Repeated administration of cocaine progressively increases drug-induced locomotor
activity. This study examined the role of dopamine D1-and D2-like receptors in the medial …

Extracellular levels of dopamine are increased in response to systemic administration of
cocaine in several brain areas including the nucleus accumbens and medial prefrontal …

Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The medial prefrontal cortex (mPFC) has been implicated in the development of behavioral
sensitization, which is the progressive enhancement of locomotor activity that occurs with …

The recent escalation of cocaine abuse has increased awareness of the need to understand
the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both …

The mesoaccumbens dopamine system is intricately involved in the locomotor stimulation
produced by cocaine and sensitization of this effect following repeated cocaine …

Background Sensitization of mesocorticolimbic dopamine projections has been a valuable
model of neurobiological adaptation to chronic exposure to cocaine and other …