Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive,
severe cognitive deficits and neuropathological hallmarks. Known risk factors for AD include …

Abnormalities in cholesterol metabolism in brain appear as an important element in
Alzheimer's disease risk and pathogenesis, as evidenced by genetic, cell-culture, mouse …

The complexity of cognitive decline involved in Alzheimer's disease (AD) warrants a
thorough investigation into the molecular mechanism that may hold the basis for the …

Research into the development of Alzheimer's disease (AD) provides increasing evidence
that vascular risk factors, including high serum cholesterol, might influence the progression …

Previous studies suggest that Alzheimer's disease (AD) neurobiology could not be
explained solely by an increase in β-amyloid levels. Recently, it has been proposed that …

Alzheimer's disease (AD) is the principal cause of dementia in older people, and
accumulation of amyloid-beta (Aβ) peptide is a crucial event in AD pathogenesis. Despite …

Cholesterol has been implicated in the pathogenesis of amyloid plaques in Alzheimer's
disease (AD) and in the formation of neurofibrillary pathology in Niemann‐Pick disease …

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the β-
amyloid protein (Aβ) in specific brain regions. Both the generation and clearance of Aβ are …

Background APOE, which is the major transporter of HDL cholesterol in the brain, is the most
significant genetic risk factor for late onset Alzheimer's Disease (AD). A large body of …

The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …